| Name | Phosphorylation activity measurement-based pathway profiling database for drug-response |
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| Aliases | phosprof |
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| Description | Phosprof (a phosphorylation activity measurement-based pathway profiling database for drug response) is a database that presents the cellular responses to representative drugs as significant pathways. It is based on the analysis of collected experimental data on the phosphorylation activities using protein arrays. The measurement of the phosphorylation activity allows the direct evaluation of the signal transduction activity and estimation of the pathways responsible for a particular cellular event. A comparison between the various approved drugs whose target phenotypes are already known can be helpful for further investigation of the drug functions and for drug development. |
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| Type | DB |
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| Main Institutes of management | National Institute of Advanced Industrial Science and Technology (AIST) |
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| Country of the Institute | Japan |
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| URL of the site | https://phosprof.medals.jp/ |
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| Interface | GUI |
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| Input example | On the top page, by selecting the check button of the cell line (MCF-7, K562), selecting the drug from the pull-down menu and pressing the submit button, the pathway containing the signature protein will be displayed. |
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| Keyword | Phosphorylation | Pathway | Signature protein | Drug |
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| Amount of the all data for download（Mbyte） | Method to obtain the all data. | 0.0|none |
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| External resources (databases) in building the product. | None |
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| Data type | Protein |
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| Biological species in the main concern | Human |
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| Conditions of use | None |
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| Frequency of updates (in last two years) | about once a year |
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| Last date of updates (date of confirmation) | 2022/03/01(2022/05/23) |
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| Main IDs used in the products | Protein ID |
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| How to make a link to get access to each IDs. | none |
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| external databases to which this database/tool have links | None |
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| Published papers (PubMed IDs) | PMID:35994309 |
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| Operational Status | available |
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