| Name | toxBridge |
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| Aliases | Toxicity bridge of drug-induced liver injury |
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| Description | toxBridge ? a statistical interpretation of building relationship between in vivo and in vitro for the purpose of constructing a panel as a marker group for predicting hepatotoxicity. Based on the rat in vivo and human in vitro gene expression data, the significance of gene signatures and pathways were analyzed for about 170 medical compounds at four dose levels and time points. The characteristics of toxBridge are focused on in vivo-in vitro and in vitro human-rat bridging, and various correlation indices between the bridges in the expression profile are stored in the database. It has the function of searching for compounds and searching for genes and pathways. This function allows the selection of which compounds are significant as bridging using correlation indices and creates a molecular panel in bridging by selecting a compound having a superior correlation index. |
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| Type | DB |
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| Main Institutes of management | National Institute of Advanced Industrial Science and Technology (AIST) |
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| Country of the Institute | Japan |
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| URL of the site | https://toxbridge.id3inst.org/top |
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| Interface | Web service |
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| Input example | None |
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| Keyword | Hepatotoxicity,DILI |
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| Amount of the all data for download（Mbyte） | Method to obtain the all data. | 1.0MB| search result |
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| External resources (databases) in building the product. | NCBI | Broad Institute | PWO |
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| Data type | Chemical compound | Gene | Pathway |
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| Biological species in the main concern | Human | Rat |
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| Conditions of use | None |
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| Frequency of updates (in last two years) | Twice a year |
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| Last date of updates (date of confirmation) | 2019/08/23 (2019/11/14) |
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| Main IDs used in the products | CAS |
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| How to make a link to get access to each IDs. | CAS |
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| external databases to which this database/tool have links | NCBI | Broad Institute | PWO |
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| Published papers (PubMed IDs) | None |
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| Operational Status | available |
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