AliasesToxicity bridge of drug-induced liver injury
DescriptiontoxBridge ? a statistical interpretation of building relationship between in vivo and in vitro for the purpose of constructing a panel as a marker group for predicting hepatotoxicity. Based on the rat in vivo and human in vitro gene expression data, the significance of gene signatures and pathways were analyzed for about 170 medical compounds at four dose levels and time points. The characteristics of toxBridge are focused on in vivo-in vitro and in vitro human-rat bridging, and various correlation indices between the bridges in the expression profile are stored in the database. It has the function of searching for compounds and searching for genes and pathways. This function allows the selection of which compounds are significant as bridging using correlation indices and creates a molecular panel in bridging by selecting a compound having a superior correlation index.
Main Institutes of managementNational Institute of Advanced Industrial Science and Technology (AIST)
Country of the InstituteJapan
URL of the site
InterfaceWeb service
Input exampleNone
Amount of the all data for download(Mbyte) | Method to obtain the all data.1.0MB| search result
External resources (databases) in building the product.NCBI | Broad Institute | PWO
Data typeChemical compound | Gene | Pathway
Biological species in the main concernHuman | Rat
Conditions of useNone
Frequency of updates (in last two years)Twice a year
Last date of updates (date of confirmation)2019/08/23 (2019/11/14)
Main IDs used in the productsCAS
How to make a link to get access to each IDs.CAS
external databases to which this database/tool have linksNCBI | Broad Institute | PWO
Published papers (PubMed IDs)None
Operational Statusavailable